논문검색
Author Young Joon Surh
Place of duty National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University Seoul, Korea.
Title Transcription Factors in the Cellular Signaling Network as Prime Targets of Chemopreventive Phytochemicals
Publicationinfo Cancer Research and Treatment 2004 Oct; 036(05): 275-286.
Key_word Chemoprevention,Phytochemicals,Signal transduction,Cell signaling network,NF- kappa B,AP-1,Mitogen-activated protein kinases,Nrf2,Keap1
Full-Text
Abstract Accumulating evidence from epidemiologic and laboratory studies support an inverse relationship between a regular consumption of fruits and vegetables and the risk of specific cancers. Numerous phytochemicals derived from edible plants have been reported to possess ability to interfere with a specific stage of carcinogenic process. Multiple mechanisms have been proposed to account for the anti-carcinogenic actions of dietary constituents, but more attention has recently focussed on intracellular signaling cascades as common molecular targets of a wide variety of chemopreventive phytochemicals. (Cancer Research and Treatment 2004;36:275-286)